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KMID : 0043320070300111380
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Archives of Pharmacal Research
2007 Volume.30 No. 11 p.1380 ~ p.1386
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Synthetic and Biological Studies on Natural Cyclic Heptapeptide: Segetalin E
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Dahiya Rajiv
Kaur Komalpreet
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Abstract
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Present investigation describes the first total synthesis of a proline-rich cyclic peptide segetalin E (8) by solution phase technique. The chemical structure of the compound was elucidated by FT-IR, 1H-NMR, 13C-NMR, FAB-MS spectral data and elemental analyses. The newly synthesized peptide was subjected to pharmacological screening and found to exhibit high cytotoxicity against Dalton뭩 lymphoma ascites (DLA) and Ehrlich뭩 ascites carcinoma (EAC) cell lines with IC50 values of 3.71 and 9.11 킡, in addition to good anthelmintic activity against earthworms M. konkanensis and P. corethruses at a dose of 2 mg/mL.
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KEYWORD
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Segetalin E, Cyclic heptapeptide, Vaccaria segetalis, Cytotoxicity, Anthelmintic activity
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